Endpoints held by each stratum, source against synthetic

One row per stratum level and endpoint, with how many source patients and how many synthetic patients contributed an observation of that endpoint. A zero on both sides is an endpoint the arm never held – a placebo arm with no pharmacokinetic concentration – and is the normal case rather than a finding. A nonzero source count against a zero synthetic count is the row to act on: that arm lost an endpoint on the way out.

Usage

compare_pmx_strata_endpoints(source, synthetic, roles)

Arguments

source

Source PMX data.

synthetic

Generated synthetic PMX data.

roles

Explicit roles from pmx_roles().

Value

A pmx_strata_endpoints data frame with level, endpoint, source_patients and synthetic_patients.

Details

Reported for the first strata column only, which is the column synpmx_scorecard() scores row C3 on. Zero rows when the roles declare no strata.

This reads real patient data on both sides and is marked "restricted_not_releasable".

See also

synpmx_scorecard(), which reports this as row C3, and compare_pmx_strata_sizes() for the size half of the same question.

Examples

data <- pmx_simulated_fixture(20)
data$ARM <- ifelse(as.integer(data$ID) %% 2L == 0L, "A", "B")
roles <- pmx_roles(
  id = "ID", time = "TIME", dv = "DV", amt = "AMT", evid = "EVID",
  cmt = "CMT", dvid = "DVID", covariates = "WT", strata = "ARM"
)
synthetic <- suppressWarnings(synpmx_avatar(data, roles, seed = 1))
#> synpmx_avatar(): dropped 9 undeclared column(s): NTIME, TAD, OCC, RATE, MDV, CENS, LIMIT, AGE, SEX.
#>   Declare a column in `keep` to carry it through verbatim.
compare_pmx_strata_endpoints(data, synthetic, roles)
#> PMX endpoints by stratum (source against synthetic)
#> 
#> ARM, patients contributing each endpoint:
#> 
#>   A / cp
#>     10 source -> 10 synthetic
#>   A / pd
#>     10 source -> 10 synthetic
#>   B / cp
#>     10 source -> 10 synthetic
#>   B / pd
#>     10 source -> 10 synthetic
#> 
#> A zero on both sides is an endpoint the arm never held.
#> Source-derived; not releasable.