The planned dose schedule each arm was generated from

One row per arm and cycle, giving the nominal time and the amount the arm was planned to receive there. The planned amount is read per cycle, so a protocol-prescribed escalation is part of the plan rather than a departure from it.

Usage

pca_dosing(x)

Arguments

x

A dataset from synpmx_pca(), or its trial summary.

Value

A data frame with arm, cycle, time and planned_amt.

Details

This is what every generated patient in the arm starts from. pca_dose_rates() gives the three hazards that then move them off it: reductions, interruptions and discontinuation. On a study with no dose modifications those rates are zero and this schedule is what every patient receives.

The grid stops at the last cycle min_arm_patients of the arm's patients reached, so a treatment duration only one patient had cannot be generated.

See also

synpmx_pca(), pca_dose_rates(), pca_visits().

Examples

data <- pmx_simulated_fixture(60)
roles <- pmx_roles(
  id = "ID", time = "TIME", nominal_time = "NTIME", dv = "DV", amt = "AMT",
  evid = "EVID", cmt = "CMT", dvid = "DVID", mdv = "MDV"
)
head(pca_dosing(synpmx_pca(data, roles, seed = 1)))
#>   arm cycle time planned_amt
#> 1 all     1    0    100.0885
#> 2 all     2   12    100.0885